T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells.

Kevin Hai-Ning LuJulius MichelMichael KilianKatrin AslanHao QiNiklas KehlStefanie JungKhwab SanghviKatharina LindnerXin-Wen ZhangEdward W GreenIsabel PoschkeMiriam RatliffTheresa BunseFelix SahmAndreas von DeimlingWolfgang WickMichael PlattenLukas Bunse

Published in: Neuro-oncology advances (2022)

transcriptional T cell states determine expansion capacity in gliomas. Our observation has important implications for the use of GIL for cell therapy including genetic manipulation to maintain both antigen specificity and expansion capacity.

Keyphrases

cell therapy
gene expression
transcription factor
stem cells
mesenchymal stem cells
heat shock
copy number
oxidative stress
bone marrow