Sex differences in metabolic effects of angiotensin-(1-7) treatment in obese mice.

Melissa C WhiteAmanda J MillerJustin LoloiSarah S BingamanBiyi ShenMing WangYuval SilbermanSarah H LindseyAmy C Arnold

Published in: Biology of sex differences (2019)

This study provides new evidence for sex differences in the impact of chronic angiotensin-(1-7) in obese mice, with females having greater changes in glucose tolerance with treatment. These findings improve understanding of sex differences in renin-angiotensin mechanisms in obesity and illustrate the potential for targeting angiotensin-(1-7) for treatment of this condition.

Keyphrases

angiotensin converting enzyme
angiotensin ii
metabolic syndrome
type diabetes
insulin resistance
weight loss
adipose tissue
risk assessment
physical activity
combination therapy
climate change