Serotonin receptor expression in hippocampus and temporal cortex of temporal lobe epilepsy patients by postictal generalized electroencephalographic suppression duration.
Dominique Frances LeitnerSasha DevoreJuliana LazeDaniel FriedmanJames D MillsYan LiuMichael JanitzJasper J AninkJohannes C BaayenSander IdemaErwin Alexander van VlietBeate DiehlCatherine ScottRoland ThijsMaromi NeiManor AskenaziShobi SivathambooTerence J O'BrienThomas M WisniewskiMaria ThomEleonora M A AronicaMaura BoldriniOrrin DevinskyPublished in: Epilepsia (2022)
Higher hippocampal 5HT2A receptor protein and potassium channel transcripts may reflect underlying mechanisms contributing to or resulting from prolonged PGES. Future studies with larger cohorts should assess functional analyses and additional brain regions to elucidate mechanisms underlying PGES and SUDEP risk.