The critical interaction between valproate sodium and warfarin: case report and review.

Chenguang ZhouYi SuiWeijin ZhaoChunyao DongLi RenPingmei SongBing XuXiaohong Sun
Published in: BMC pharmacology & toxicology (2018)
By reviewing the literature and discussing the critical interaction between valproate sodium and warfarin, we conclude that intravenous VPA and the co-administrated warfarin may develop critical but underrecognized complications due to effects on the function of hepatic enzymes and displacement of protein binding sites.