Evaluation of the new Abbott®Alinity assay for the measurement of thyroglobulin antibodies in patients with differentiated thyroid carcinoma.

The coefficients of variation (standard deviation as a percentage of the mean %CV) for the Alinity Abbott kit reagent TgAb were within 10% included the functional sensitivity. On the other hand, the concordance analysis with the kappa index concluded substantial agreement. Mc Nemar's Test showed a significant difference between Alinity vs. Centaur second generation (Difference 8.33%, CI95% 0.68-8.33, p=0.0313) Conclusion: The new methodology for the measurement of TgAb meets the imprecision standards while presenting an adequate concordance agreement with other methodologies available in laboratories. It is important to define the functional sensitivity when reporting results so that they are as reliable as possible.