Influence of contraindicated medication use on cognitive outcome in Dravet syndrome and age at first afebrile seizure as a clinical predictor in SCN1A-related seizure phenotypes.
Iris M de LangeBoudewijn GunningAnja C M SonsmaLisette van GemertMarjan van KempenNienke E VerbeekJoost NicolaiNine V A M KnoersBobby P C KoelemanEva H BrilstraPublished in: Epilepsia (2018)
Our data suggest that a longer CIM use in the first 5 years of disease can have negative effects on cognitive outcome in Dravet syndrome. An early diagnosis is essential to avoid these drugs. Furthermore, we identified age at first afebrile seizure as an important predictor for evolution of seizures into Dravet syndrome and for the severity of Dravet syndrome, which can be used to counsel parents of young patients with SCN1A-related seizures.