Genetic profiles of oligometastatic non-small-cell lung cancer and corresponding brain metastases.

Raphael S WernerMarkus RechsteinerHolger MochAlessandra Curioni-FontecedroMichael WellerTobias WeissLuca Regli Emilie Le RhunFabian MairingerIsabelle OpitzAlex Soltermann

Published in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2024)

In oligometastatic NSCLC, BM retain the main genetic alterations of the primary tumours. Patients may profit from targeted inhibition of mutated KRAS. Additional private genetic alterations in the BM are dismal.

Keyphrases

brain metastases
small cell lung cancer
genome wide
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
copy number
healthcare
patient reported outcomes
drug delivery
epidermal growth factor receptor