Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV-1.

Victoria Armario-NajeraAmaya Blanco-PereraShilpa R ShenoyYi SunSilvia MarfilJordana Muñoz-BasagoitiDaniel Perez-ZsoltJulià BlancoNuria Izquierdo-UserosTeresa CapellBarry R O'KeefePaul Christou

Published in: Plant cell reports (2022)

~ 11.5 °C) and doubled the enthalpy of unfolding, suggesting a dimerization event. The similar melting phenomenon shared by SVN and SD1 in the presence of oligomannose confirmed their conserved oligosaccharide-binding mechanisms. SD1 expressed in transgenic rice was able to neutralize HIV-1 in vitro. SD1 expressed in rice, therefore, is suitable as a microbicide component.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
high resolution
transcription factor
cell free
dna binding