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Sinomenine attenuates bleomycin-induced pulmonary fibrosis, inflammation, and oxidative stress by inhibiting TLR4/NLRP3/TGFβ signaling.
Yijue Liu
Hong Chen
Yan Wu
Fen Ai
Wei Li
Huan Peng
Feng Gui
Bo Yu
Zhen Chen
Published in:
Inhalation toxicology (2024)
Sinomenine attenuates BLM-caused pulmonary fibrosis, inflammation, and oxidative stress by inhibiting the TLR4/NLRP3/TGFβ signaling, indicating that sinomenine might become a therapeutic candidate to treat pulmonary fibrosis.
Keyphrases
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pulmonary fibrosis
oxidative stress
diabetic rats
toll like receptor
inflammatory response
transforming growth factor
signaling pathway
dna damage
ischemia reperfusion injury
induced apoptosis
immune response
high glucose
nuclear factor
nlrp inflammasome
drug induced
heat shock
endoplasmic reticulum stress