The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli.
Wen-Chun HuangChung-Yen LinMasayuki HashimotoJiunn-Jong WuMing-Cheng WangWei-Hung LinChang-Shi ChenChing-Hao TengPublished in: Journal of biomedical science (2020)
We demonstrated for the first time that Prc is essential for full ExPEC virulence in UTIs. Our results collectively support the idea that Prc is essential for bacterial envelope integrity, thus explaining how Prc deficiency results in an attenuated ExPEC.