Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing.
Rubén López-AladidAlba GuiuMaria Mar MosqueraFrancisco López-MedranoFrederic CofánLaura LinaresJulián Torre-CisnerosElisa VidalAsunción MorenoJose María AguadoElisa CorderoCecilia Martin-GandulJordi CarrataláNuria SabéJordi NiubóCarlos CerveraAlicia CapónAnna CervillaMarta Santos BravoMarta BodroPatricia MuñozMaria Carmen FariñasAndrés AntónMaitane AranzamendiMiguel MontejoPilar Pérez-RomeroOscar LenMaria Ángeles MarcosPublished in: PloS one (2019)
NGS showed a higher yield than Sanger sequencing for detecting CMV resistance mutations in SOT recipients. The presence of DRM detected by NGS was independently associated with longer antiviral treatment.