Into the unknown: Diagnosing mysterious brain lesions.
Ihab KassabCarlos IsadaMarwan Mikheal AzarNadine SarsamMin JiangSandra Camelo-PiraguaDaniel KaulMaricar MalinisPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2022)
In this inaugural clinicopathological conference, the invited experts discussed the diagnostic approach to central nervous system infections in immunocompromised hosts. The case presented involved a pancreas-kidney transplant recipient with multiple brain abscesses caused by Bartonella henselae. CSF metagenomic next-generation sequencing played a significant role in the diagnosis. Bartonella henselae is a gram-negative zoonotic pathogen that causes cat-scratch disease, which can be transmitted to humans through cat bites or scratches. Symptoms can vary in severity, correlating with the patient's immune status. Visceral organ involvement, ocular involvement, and neurological manifestations have been reported in immunocompromised patients, but brain abscesses are rare.
Keyphrases
- gram negative
- resting state
- white matter
- multidrug resistant
- end stage renal disease
- cerebral ischemia
- functional connectivity
- newly diagnosed
- chronic kidney disease
- ejection fraction
- case report
- prognostic factors
- insulin resistance
- cerebrospinal fluid
- intensive care unit
- gene expression
- patient reported outcomes
- copy number
- dna methylation
- sleep quality
- depressive symptoms
- acute respiratory distress syndrome
- genome wide