Pharmacogenetics of aminoglycoside-related ototoxicity: a systematic review.

D GaafarN BaxterN CranswickJohn ChrisodoulouA Gwee

Published in: The Journal of antimicrobial chemotherapy (2024)

This review found that the m.1555A > G and m.1494C > T variants in the MT-RNR1 gene have the strongest evidence in the development of AG-related SNHL, although study quality was limited (level 2-4). These variants were associated with high penetrance of a SNHL phenotype following AG exposure.

Keyphrases

copy number
quantum dots
pseudomonas aeruginosa
highly efficient
quality improvement
cystic fibrosis
acinetobacter baumannii
drug induced
transcription factor