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Pharmacogenetics of aminoglycoside-related ototoxicity: a systematic review.

D GaafarN BaxterN CranswickJohn ChrisodoulouA Gwee
Published in: The Journal of antimicrobial chemotherapy (2024)
This review found that the m.1555A > G and m.1494C > T variants in the MT-RNR1 gene have the strongest evidence in the development of AG-related SNHL, although study quality was limited (level 2-4). These variants were associated with high penetrance of a SNHL phenotype following AG exposure.
Keyphrases
  • copy number
  • quantum dots
  • pseudomonas aeruginosa
  • highly efficient
  • quality improvement
  • cystic fibrosis
  • acinetobacter baumannii
  • drug induced
  • transcription factor