How to and should we target EBV in MS?
Svetlana EckertDejan JakimovskiRobert ZivadinovMark HicarBianca Weinstock-GuttmanPublished in: Expert review of clinical immunology (2024)
Recent strong epidemiological findings support that EBV may be the primary inducing event in certain individuals that shortly thereafter develop MS. More studies are needed in order to better understand the significant variability in susceptibility based on environmental factors such as EBV exposure. Future investigations should focus on determining the specific EBV-related risk antigen(s) and phenotyping people with likely EBV-induced MS. Targeting EBV via several different avenues, including development of an EBV vaccine, may become the mainstay of MS treatment in the future.