Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination.
Jana Sophia BuhreTamas PongraczUlf Martin GeisenMareike SchubertWenjun WangJan NoutaMaureen ObaraSelina LehrianJohann RahmöllerJanina PetryFlorian TranStefan SchreiberMelike SümbülDennis BernerSascha GerdesJan SchirmerAnn Carolin LongardtPaula HoffUlrich KalinkeRalf J LudwigYannic C BartschBimba F HoyerManfred WuhrerMarc EhlersPublished in: Allergy (2024)
The data suggest that anti-TNF treatment reduces both GC-dependent long-lived PCs and GC-dependent memory B cell-derived short-lived PCs, hence both the long- and short-term IgG subclass responses, respectively, after repeated vaccination. We propose that anti-TNF therapy, especially in the elderly, reduces the benefit of booster vaccination.