An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma.
Lei LiuHyunchang KwakTrebor L LawtonShan-Xue JinAngela L MeunierYifan DangBeth OstaszewskiAlison C PietrasAndrew M SternDennis J SelkoePublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
We have created a sensitive, high throughput, and inexpensive method to quantify synaptotoxic oAβ in human plasma for analyzing large cohorts of aged and AD subjects to assess the dynamics of this key pathogenic species and response to therapy.