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aRNAque: an evolutionary algorithm for inverse pseudoknotted RNA folding inspired by Lévy flights.

Nono S C MerleauMatteo Smerlak
Published in: BMC bioinformatics (2022)
We propose that a Lévy flight offers a better standard mutation scheme for optimizing RNA design. Our new version of aRNAque is available on GitHub as a python script and the benchmark results show improved performance on both Pseudobase++ and the Eterna100 datasets, compared to existing inverse folding tools.
Keyphrases
  • single molecule
  • molecular dynamics simulations
  • machine learning
  • deep learning
  • nucleic acid
  • genome wide
  • rna seq
  • gene expression
  • neural network
  • single cell