Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice.

Qiuhua YangQian MaJiean XuZhiping LiuXiaoxiao MaoYaqi ZhouYongfeng CaiQingen DaMei HongNeal L WeintraubDavid J FultonEric J Belin de ChantemèleYuqing Huo

Published in: British journal of pharmacology (2021)

This unexpected pro-inflammatory effect of endothelial AMPKα1/PRKAA1 in metabolic context provides additional insight in AMPKα1/PRKAA1 activities, warranting that in-depth study and thoughtful consideration should be applied when AMPKα1/PRKAA1 is used as a therapeutic target in the treatment of metabolic syndrome.

Keyphrases

skeletal muscle
metabolic syndrome
protein kinase
endothelial cells
oxidative stress
insulin resistance
high fat diet
adipose tissue
uric acid