PET imaging of hepatocellular carcinoma with anti-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in comparison with L-[S-methyl-11C]methionine.
Olga SergeevaYifan ZhangJonathan D KenyonGalen A Miller-AtkinsChunying WuRenuka IyerSandra SextonPatrick WojtylakAmad AwadallahWei XinE Ricky ChanJames K O'DonnelZhenghong LeePublished in: EJNMMI research (2019)
Both [18F]FACBC and [11C]Met showed uptake in HCC through the use of a clinically relevant animal model of woodchuck HCC. The uptake and retention of [18F]FACBC and [11C]Met depend on their metabolism and also rely on the distribution of their principal amino acid transporters.