Long-term imatinib diminishes ovarian reserve and impacts embryo quality.

Wael SalemJacqueline R HoIrene WooSue A InglesKarine ChungRichard J PaulsonLynda K McGinnis

Published in: Journal of assisted reproduction and genetics (2020)

This pilot study indicates that long-term TKI treatments may have significant impact on ovarian reserve and embryo developmental capacity. More studies are needed in other model systems to determine the long-term impact of TKIs in patients. Knowing the potential effects of chemotherapeutics on reproductive outlook is critical for quality of life and more research is needed.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
prognostic factors
chronic myeloid leukemia
pregnant women
climate change
patient reported outcomes
patient reported