HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model.
Yi-Fu HeXi-Min HuMd Asaduzzaman KhanBo-Yao YuYi-Cun ShengXian-Zhong XiaoXin-Xing WanSi-Pin TanKun XiongPublished in: Mediators of inflammation (2023)
These results imply that HSF1 could alleviate sepsis-induced brain injury by inhibiting pyroptosis through the NLRP3-dependent pathway in brain tissue and PC12 cells, suggesting HSF1 as a potential molecular target for treating brain injury in sepsis clinical studies.
Keyphrases
- brain injury
- cerebral ischemia
- nlrp inflammasome
- white matter
- heat shock
- resting state
- septic shock
- acute kidney injury
- intensive care unit
- subarachnoid hemorrhage
- high glucose
- diabetic rats
- signaling pathway
- functional connectivity
- multiple sclerosis
- endothelial cells
- blood brain barrier
- single molecule
- human health
- heat shock protein