Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma.
Siqi LiaoQingliang WangSiyuan ChenQixuan HuangLi ZhouHongtao LiuSong HeZhi-Hang ZhouPublished in: Journal of translational medicine (2024)
Through high throughput screening, we identified that Mito-LND and (E)-Akt inhibitor-IV are two novel compounds against both parental and drug-resistant HCC cells, which could offer new strategies for HCC patients.
Keyphrases
- drug resistant
- induced apoptosis
- endoplasmic reticulum stress
- signaling pathway
- multidrug resistant
- end stage renal disease
- acinetobacter baumannii
- cell proliferation
- newly diagnosed
- ejection fraction
- prognostic factors
- oxidative stress
- peritoneal dialysis
- cell cycle arrest
- patient reported outcomes
- pi k akt
- reactive oxygen species