Pyruvate dehydrogenase kinase 4 promotes ubiquitin-proteasome system-dependent muscle atrophy.

Ibotombi Singh SinamDipanjan ChandaThemis ThoudamMin-Ji KimByung-Gyu KimHyeon-Ji KangJung Yi LeeSeung-Hoon BaekShin-Yoon KimBum Jin ShimDongryeol RyuJae-Han JeonIn-Kyu Lee
Published in: Journal of cachexia, sarcopenia and muscle (2022)
We have demonstrated that PDK4 mediates dexamethasone-induced skeletal muscle atrophy. Mechanistically, PDK4 phosphorylates and degrades myogenin via recruitment of E3 ubiquitin ligase, muscle atrophy F-box. Rescue of muscle regeneration by genetic ablation of PDK4 or overexpression of non-phosphorylatable myogenin mutant indicates PDK4 as an amenable therapeutic target in muscle atrophy.