Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders.
Julian MacoveanuJeff Zarp PetersenPatrick MacDonald FisherLars Vedel KessingGitte Moos KnudsenKamilla Woznica MiskowiakPublished in: Psychological medicine (2023)
Our findings suggest that cognitive impairments across BD and UD are associated with insufficient recruitment of task-relevant regions in the CCN and down-regulation of task-irrelevant orbitofrontal activity within the DMN during task performance. Specifically, a lower recruitment of the left posterior SFG within CCN during verbal WM was associated with lower cognitive performance.