Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model.

Yu Jung HeoSung-E ChoiNami LeeJa Young JeonSeung Jin HanDae Jung KimYup KangKwan Woo LeeHae Jin Kim

Published in: Journal of gastroenterology and hepatology (2021)

These results suggest that visfatin aggravates hepatic inflammation together with induction of ER and oxidative stress and exacerbates fibrosis in an MCD-diet-fed mouse model of NAFLD.

Keyphrases

oxidative stress
mouse model
physical activity
weight loss
ischemia reperfusion injury
dna damage
diabetic rats
induced apoptosis
signaling pathway
endoplasmic reticulum
heat shock
heat shock protein