Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension.
Samuel B BruscaJason M ElinoffYvette ZouMoon Kyoo JangHyesik KongCumhur Y DemirkaleJunfeng SunFayaz SeifuddinMehdi PiroozniaHannah A ValantineCarl TanbaAbhishek ChaturvediGrace M GraningerBonnie HarperLi-Yuan ChenJustine ColeManreet K KanwarRaymond L BenzaIoana R PrestonSean Agbor-EnohMichael A SolomonPublished in: Circulation (2022)
Circulating cfDNA is elevated in patients with PAH, correlates with disease severity, and predicts worse survival. Results from cfDNA methylation analyses in patients with PAH are consistent with prevailing paradigms of disease pathogenesis.