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Inhibitory effects of Eplerenone on angiogenesis via modulating SGK1/TGF-β pathway in contralateral kidney of CKD pregnancy rats.
Wenping Zhou
Chang Xu
Jieqi Niu
Yunzhao Xiong
Zhen He
Hepeng Xu
Mengjuan Zhang
Hongshuang Wang
Qingyou Xu
Xiangting Wang
Zheng Wang
Published in:
Cellular signalling (2024)
Eplerenone inhibits renal angiogenesis by blocking the SGK-1/TGFβ signal transduction pathway, thereby inhibiting the phenotypic transformation of endothelial cells, slowing down renal fibrosis, and reducing kidney damage caused by pregnancy.
Keyphrases
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endothelial cells
transforming growth factor
vascular endothelial growth factor
preterm birth
signaling pathway
high glucose
pregnancy outcomes
chronic kidney disease
oxidative stress
wound healing
epithelial mesenchymal transition
pregnant women