Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study.
Mona AbdiElbay AliyevBrett TrostMuhammad KohailanWaleed AamerNajeeb SyedRulan ShaathGeethanjali Devadoss GandhiWorrawat EngchuanJennifer HoweBhooma ThiruvahindrapuramMelissa GengJoe WhitneyAmira SyedJyothi LakshmiSura HusseinNajwa AlbashirAmal HusseinIlaria PoggioliniSaba F ElhagSasirekha PalaniswamyMarios KambourisMaria de Fatima JanjuaMohamed O El TahirAhsan NazeerDurre ShahwarMuhammad Waqar AzeemYounes MokrabNazim Abdel AatiAmmira AkilStephen W SchererMadeeha KamalKhalid A FakhroPublished in: Genome medicine (2023)
This study illustrates the value of ASD studies in under-represented populations and the importance of WGS as a comprehensive tool for establishing a molecular diagnosis for families with ASD. Moreover, it uncovers a significant role for recessive variation in ASD architecture in consanguineous settings and provides a unique resource of Middle Eastern genomes for future research to the global ASD community.