Prognostic impact of variant histologies in urothelial bladder cancer treated by radical cystectomy.
Francesco ClapsMaaike W van de KampRoman MayrPeter J BostromShahrokh F ShariatKatrin HippeSimone BertzYann NeuzilletJoyce SandersWolfgang OttoMichiel S van der HeijdenMichael A S JewettRobert StöhrAlexandre R ZlottaCarlo TrombettaMarkus EcksteinLaura S MertensMaximilian BurgerYanish SoorojeballyBernd WullichRiccardo BartolettiFrançois RadvanyiNicola PavanNanour SirabMaria Carmen Mir MaresmaDamien PouesselTheo H van der KwastArndt HartmannYair LotanRossana BussaniYves AlloryBas W G van RhijnPublished in: BJU international (2023)
More than 25% of patients harbored a VH at time of RC. Compared to pure UC, clear-cell, plasmacytoid, small-cell and sarcomatoid VHs were associated with worse DSS while lymphoepithelioma-like VH was characterized by a DSS benefit. Accurate pathologic diagnosis of VHs may ensure a tailored counselling to identify patients who require more intensive management.
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