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Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population.

Hanieh YaghootkarF AbbasiN GhaemiA RabbaniM N WakelingP EshraghiS EnayatiS VakiliS HeidariK PatelF SayarifardS Borhan-DayaniT J McDonaldS EllardA T HattersleyM M AmoliR VakiliK Colclough
Published in: Diabetic medicine : a journal of the British Diabetic Association (2019)
The present study provides the first evidence that Type 1 diabetes genetic risk score can be used to distinguish monogenic from Type 1 diabetes in an Iranian population with a large number of consanguineous unions. This test can be used to identify children with a higher probability of having monogenic diabetes who could then undergo genetic testing. Identification of these individuals would reduce the cost of treatment and improve the management of their clinical course.
Keyphrases
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • insulin resistance
  • genome wide
  • gene expression
  • adipose tissue
  • skeletal muscle
  • bioinformatics analysis