Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population.
Hanieh YaghootkarF AbbasiN GhaemiA RabbaniM N WakelingP EshraghiS EnayatiS VakiliS HeidariK PatelF SayarifardS Borhan-DayaniT J McDonaldS EllardA T HattersleyM M AmoliR VakiliK ColcloughPublished in: Diabetic medicine : a journal of the British Diabetic Association (2019)
The present study provides the first evidence that Type 1 diabetes genetic risk score can be used to distinguish monogenic from Type 1 diabetes in an Iranian population with a large number of consanguineous unions. This test can be used to identify children with a higher probability of having monogenic diabetes who could then undergo genetic testing. Identification of these individuals would reduce the cost of treatment and improve the management of their clinical course.