Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support.
Stavros G DrakosRachit BadoliaAman MakajuChristos P KyriakopoulosOmar Wever-PinzonChristopher M TracyAnna A BakhtinaRyan BiaTimothy J ParnellIosif TalebDinesh K A RamaduraiSutip NavankasattusasElizabeth DranowThomas C HanffEleni TseliouThirupura S ShankarJoseph R ViskerRana HamoucheElizabeth L StauderWilliam T CaineRami AlharethiCraig H SelzmanSarah FranklinPublished in: Circulation (2022)
This is the first study to characterize changes in the nonfailing and failing human heart by integrating multiple -omics platforms to identify molecular indices defining patients capable of myocardial recovery. These findings may guide patient selection for advanced HF therapies and identify new HF therapeutic targets.