Clinical Course and Impact of Immune Checkpoint Inhibitor Colitis Resembling Microscopic Colitis.
Thomas W FredrickGuilherme Piovezani RamosManuel B Braga NetoSunanda V KaneWilliam A FaubionEdward V LoftusDarrell S PardiShabana F PashaFrancis A FarrayeLizhi ZhangLaura E RaffalsPublished in: Crohn's & colitis 360 (2022)
MC can develop after ICI administration, and presents with severe symptoms, often requiring hospitalization and steroid treatment. In certain individuals this can require a prolonged treatment course of steroid therapy or immunomodulators. Individuals developing diarrhea after ICI therapy warrant thorough workup including endoscopy and rapid treatment initiation given the disease severity observed in this series.