Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer.

Stephanie O DudzinskiBrent D CameronJian WangJeffrey C RathmellTodd D GiorgioAustin N Kirschner

Published in: Journal for immunotherapy of cancer (2019)

Castration-resistant prostate cancer in a wild-type mouse model is successfully treated by X-ray radiotherapy combined with PD-1 or PD-L1 immune checkpoint inhibition, demonstrating significantly increased median overall survival and robust local and abscopal treatment responses, in part mediated by CD8 T-cells.

Keyphrases

mouse model
wild type
early stage
locally advanced
radiation therapy
radiation induced
high resolution
rectal cancer
magnetic resonance imaging
computed tomography
magnetic resonance
mass spectrometry
free survival