The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.

Marisa KlopperCharnay J van der MerweYuri F van der HeijdenMegan FolkertsJohannes LoubserElizabeth M StreicherKate MeklerCindy HayesDavid M EngelthalerJohn Z MetcalfeRobin M Warren

Published in: Annals of the American Thoracic Society (2024)

Among patients with rifampin-susceptible TB diagnosed using first-line molecular TB assays, there is a high prevalence of Hr-TB. Phenotypic DST remains the gold standard. To improve performance of genetic-based phenotyping tests, all isoniazid resistance associated regions should be included, and such tests should have the ability to identify underlying mutations.

Keyphrases

mycobacterium tuberculosis
south africa
pulmonary tuberculosis
high throughput
hiv positive
genome wide
copy number
gene expression
dna methylation
adverse drug