STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry.

Carlos Pascual-CaroMaria BerrocalAida M Lopez-GuerreroAlberto Alvarez-BarrientosEulalia Pozo-GuisadoCarlos Gutierrez-MerinoAna M MataFrancisco Javier Martin-Romero

Published in: Journal of molecular medicine (Berlin, Germany) (2018)

STIM1 protein expression decreases with the progression of neurodegeneration in Alzheimer's disease. STIM1 is essential for cell viability in differentiated SH-SY5Y cells. STIM1 deficiency triggers voltage-regulated Ca2+ entry-dependent cell death. Mitochondrial dysfunction and senescence are features of STIM1-deficient differentiated cells.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
signaling pathway
pi k akt
oxidative stress
cognitive decline
cell proliferation
endothelial cells
transcription factor