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Association of IL-33 in modeling type-2 airway inflammation and pulmonary emphysema in mice.

Chika MiyaokaMasato WatanabeKeitaro NakamotoYuki YoshidaAya HirataJumpei AsoHiroki NunokawaManabu IshidaKoujiro HondaSaori TakataTakeshi SarayaHaruyuki Ishii
Published in: Immunity, inflammation and disease (2024)
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL-13), IL-4, and IL-5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL-33 level in the lung was higher than in other models. IL-33 and interferon-γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung.
Keyphrases
  • pulmonary hypertension
  • chronic obstructive pulmonary disease
  • mouse model
  • lung function
  • immune response
  • dendritic cells
  • type diabetes
  • metabolic syndrome
  • insulin resistance
  • air pollution