High Irisin levels in nondiabetic HIV-infected males are associated with insulin resistance, nonalcoholic fatty liver disease, and subclinical atherosclerosis.
Oscar Moreno-PerezRebeca Reyes-GarciaManuel Muñoz-TorresEsperanza MerinoVicente BoixSergio ReusLivia GinerRocío AlfayateBeatriz Garcia-FontanaJose Sanchez-PayaAntonio PicóJoaquín PortillaPublished in: Clinical endocrinology (2018)
In male HIV patients without diabetes, higher irisin concentrations are positively associated with insulin resistance, NAFLD and subclinical atherosclerosis. However, waist-hip-ratio is the main determinant of insulin resistance, and PAI-1 and lipodystrophy were the strongest determinants of IMT in this population.
Keyphrases
- insulin resistance
- hiv infected
- type diabetes
- antiretroviral therapy
- adipose tissue
- cardiovascular disease
- high fat diet
- metabolic syndrome
- polycystic ovary syndrome
- skeletal muscle
- end stage renal disease
- glycemic control
- high fat diet induced
- ejection fraction
- human immunodeficiency virus
- newly diagnosed
- body mass index
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- hiv aids
- hiv testing
- patient reported outcomes
- physical activity
- liver fibrosis
- total hip arthroplasty