Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.

Tatyana StrekalovaYanzhi LiuDaniel KiselevSharafuddin KhairuddinJennifer Lok Yu ChiuJustin LamYing-Shing ChanDmitrii PavlovAndrey ProshinKlaus-Peter LeschDaniel Clive AnthonyLee Wei Lim

Published in: Psychopharmacology (2022)

We propose methodological revisions and the use of more advanced behavioral tests to refine the rat CMS paradigm, which offers a valuable tool for developing new antidepressant medications.

Keyphrases

major depressive disorder
depressive symptoms
oxidative stress
sleep quality
stress induced
image quality
magnetic resonance imaging
magnetic resonance