Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study.
Cornelis SmitRoeland E WasmannMarinus J WiezerHendricus P A van DongenJohan W MoutonRoger J M BrüggemannCatherijne A J KnibbePublished in: Pharmaceutical research (2019)
In obese and non-obese individuals with normal renal function, renal function estimates such as MDRD were identified as best predictors for tobramycin clearance, which may imply that other processes are involved in clearance of tobramycin versus gentamicin. To ensure similar exposure across body weights, we propose a MDRD-based dosing nomogram for obese patients.