DNA Methylation of CD70 Promoter in Juvenile Systemic Lupus Erythematosus.

Mahsa Keshavarz-FathiGolshid SanatiMaryam SadrBahareh MohebbiVahid ZiaeeNima Rezaei

Published in: Fetal and pediatric pathology (2020)

Despite hypomethylation of CD70 gene promoter in CD4+ T-cells from adult patients with SLE, no statistically significant differences observed in patients with JSLE compared with healthy controls. This may suggest a mechanism different in JSLE patients than in adults.

Keyphrases

dna methylation
systemic lupus erythematosus
genome wide
gene expression
end stage renal disease
disease activity
transcription factor
newly diagnosed
nk cells
ejection fraction
peritoneal dialysis
copy number
patient reported outcomes