In vitro and in vivo characterization of cancer stem cell subpopulations in oral squamous cell carcinoma.
Nádia Ghinelli AmôrRodrigo Fonseca BuzoRafael Carneiro OrtizNathália Martins LopesLuciana Mieli SaitoIan Campbell MackenzieCamila de Oliveira Rodini PegoraroPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)
Our results suggest that while cells in the Epi-CSC form the subpopulation that enables tumor growth, the EMT-CSC are related to migration and invasion. Clinically, this may reflect the importance of Epi-CSC for tumorigenesis and of the EMT-CSC for metastasis and highlights that variation in the proportion of CSC phenotypes from patient to patient may be relevant to the design of individual treatment protocols.