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Discordance between PAM50 intrinsic subtyping and immunohistochemistry in South African women with breast cancer.

Thérèse Dix-PeekBoitumelo P PhakathiEunice J van den BergCaroline DickensTanya N AugustineHerbert CubaschAlfred I NeugutJudith S JacobsonMaureen JoffePaul RuffRaquel A B Duarte
Published in: Breast cancer research and treatment (2023)
We suggest that the Ki67 be changed to a cutoff of 20-25% in our population to better reflect the luminal subtype classifications. This change would inform treatment options for breast cancer patients in settings where genomic assays are unaffordable.
Keyphrases
  • high throughput
  • copy number
  • neoadjuvant chemotherapy
  • gene expression
  • dna methylation
  • radiation therapy