miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.

Yongwen LiHongbing ZhangHao GongYin YuanYing LiCong WangWeiting LiZihe ZhangMinghui LiuHongyu LiuJun Chen

Published in: Journal of experimental & clinical cancer research : CR (2018)

Collectively, our results demonstrated that miR-182 targeted CTTN gene in NSCLC and suppressed lung cancer invadopodia formation, and thus suppressed lung cancer metastasis. This suggests a therapeutic application of miR-182 in NSCLC.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
small cell lung cancer
copy number
genome wide
advanced non small cell lung cancer
signaling pathway
genome wide identification
drug delivery
brain metastases
tyrosine kinase
epidermal growth factor receptor