Zirconium Oxide Thin Films Obtained by Atomic Layer Deposition Technology Abolish the Anti-Osteogenic Effect Resulting from miR-21 Inhibition in the Pre-Osteoblastic MC3T3 Cell Line.

Aleksandra Seweryn Ariadna Pielok Krystyna Ławniczak-Jabłońska Rafal Pietruszka Klaudia Marcinkowska Mateusz Sikora Bartlomiej S Witkowski Marek Godlewski Krzysztof Marycz Agnieszka Smieszek

Published in: International journal of nanomedicine (2020)

The data obtained indicate that ZrO2 coatings created using the ALD method may have pro-osteogenic properties and may improve the metabolism of bone precursor cells. Given the above, further development of ZrO2 ALD layers is essential in terms of their potential clinical application in bone regenerative medicine.

Keyphrases

mesenchymal stem cells
bone mineral density
bone marrow
induced apoptosis
cell proliferation
long non coding rna
bone loss
soft tissue
cell cycle arrest
bone regeneration
long noncoding rna
postmenopausal women
big data
signaling pathway
vascular smooth muscle cells
cell death
pi k akt