Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting.

Philippa RandallJunior MutsvangwaMarriott NliwasaLindsay WilsonBeauty MakamureEdson MakambwaRichard MeldauKeertan DhedaShungu MunyatiOmar SiddiqiElizabeth CorbettAli Esmail

Published in: Open forum infectious diseases (2024)

As a same-day rule-in test, IRISA-TB had significantly better sensitivity than Xpert Ultra in a TB/HIV-endemic setting. An immunodiagnostic approach to TBM is promising, and further studies are warranted.

Keyphrases

mycobacterium tuberculosis
cerebrospinal fluid
hiv aids
antiretroviral therapy
pulmonary tuberculosis
hiv infected
hepatitis c virus
hiv testing
dendritic cells
emergency department
immune response
adverse drug