Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.

Lena ErkertReyes Gamez-BelmonteMelanie KabischLena SchödelJay V PatankarMiguel Gonzalez-AceraMousumi MahapatroLi-Li BaoChristina PlattnerAnja A KühlJie ShenLutgarde SerneelsBart De Stroopernull nullMarkus Friedrich NeurathStefan WirtzChristoph Becker

Published in: Gut (2024)

Overall, our study provides evidence that Psen1 and Psen2 are important guardians of intestinal homoeostasis and future targets for barrier-promoting therapeutic strategies in IBD.

Keyphrases

early onset
cognitive decline
current status
mild cognitive impairment
ulcerative colitis
drug induced