IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice.

Huijun YuanShaoyi ChenMatthew R DuncanJuan Pablo de Rivero VaccariRobert W KeaneW Dalton DietrichTsung-Han ChouMerline BennyAugusto F SchmidtKaren YoungKevin K ParkVittorio PorciattiM Elizabeth HartnettShu Wu

Published in: Angiogenesis (2024)

These data demonstrate the crucial role of ASC in the pathogenesis of OIR and the efficacy of a humanized therapeutic anti-ASC antibody in treating OIR mice. Thus, this anti-ASC antibody may potentially be considered in diseases associated with oxygen stresses and retinopathy, such as ROP.

Keyphrases

nlrp inflammasome
high fat diet induced
monoclonal antibody
electronic health record
machine learning
metabolic syndrome
skeletal muscle
insulin resistance
drug induced
endothelial cells