Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors.
Xuefeng WangTingyi LiIslam EljilanyVineeth SukrithanAakrosh RatanMartin McCarterJohn CarptenHoward ColmanAlexandra P IkeguchiIgor PuzanovSusanne ArnoldMichelle ChurchmanPatrick HwuPaulo C RodriguezWilliam S DaltonGeorge J WeinerAhmad A TarhiniPublished in: medRxiv : the preprint server for health sciences (2024)
Our findings offer important insights into refining the patient selection process for immunotherapy in real-world practice and guiding the creation of novel therapeutic strategies to target specific ecotypes within the TME.