Where is the Macrocycle? Comment on "Simultaneous Organic and Inorganic Host-Guest Chemistry within Pillararene-Protein Cage Frameworks."

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2023)

Kostiainen and co-workers claim to have prepared crystals of ferritin by "electrostatically bridging" the protein with a cationic pillar[5]arene. Questions remain regarding the contribution of the pillar[5]arene to protein assembly and the putative role as a molecular glue.

Keyphrases

water soluble
protein protein
amino acid
binding protein
small molecule
drug discovery
room temperature