A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships.

Published in: Genome biology (2022)

We have generated an integrated chromatin interaction network which complements a large number of methodological and analytic approaches focused on improved specificity or interpretation. This high-depth "super-experiment" is surprisingly powerful in capturing long-range functional relationships of chromatin interactions, which are now able to predict coexpression, eQTLs, and cross-species relationships. The meta-Hi-C networks are available at https://labshare.cshl.edu/shares/gillislab/resource/HiC/ .

Keyphrases

high density
dna damage
gene expression
transcription factor
genome wide
network analysis
oxidative stress
structural basis